Hiroshi Nishino (born in 1955)

Professor of Department of Chemistry,  Faculty of Science, Kumamoto University TEL : +81(Japan)-96-342-3374 FAX : +81(Japan)-96-342-3371 E-mail : nishino@aster.sci.kumamoto-u.ac.jp

Research Interests

Free-Radical Cyclization of Organic Compounds Using Transition Metal Complexes:

synthesis of lactones, furans, 4,5-dihydrofurans, 1,2-dioxanes, and bicyclic, tricyclic, and macrocyclic compounds

Metal-Catalyzed Oxidation of Organic Molecules:

synthesis of epoxides, substituted 4,4'-biphenyldiols and 4,4'-diphenoquinones

Carbon-Carbon Bond Formation under High Pressure:

direct diacetylmethylation of aromatic compounds

Photo-Induced Intramolecular Cyclization and Photooxygenation of Organic Compounds:

synthesis of substituted naphthalenes and oxiranes

Separation and Total Synthesis of Natural Products:

synthesis of pyrrolo[1,4]benzodiazepine antibiotics

Bibliography

• 1999-1996
• (Nitrosonaphtholato)metal Complex-Catalyzed Oxidation of Phenols and Alkenes, Hiroshi Nishino, Hideaki Satoh, Mayumi Yamashita, and Kazu Kurosawa, J. Chem. Soc., Perkin Trans 2,1999, 1919-1924.
• Palladium-Catalyzed Hydrogenolysis of Azabicyclic Peroxides. Quantitative Transformation to 1-Hydroxy-7-aza-2-oxabicyclo[3.3.0]octanes, Firoz Alam Chowdhury, Shougo Kajikawa, Hiroshi Nishino, and Kazu Kurosawa, Tetrahedron Lett.,1999, 40,3765-3768.
• Manganese(III)-Based Oxidative Radical Cyclization of Terminal Alkadienes with N,N'-Bis(3-oxobutanoyl)-a,w-alkanediamines. Formation of Macrodiamides, Firoz Alam Chowdhury, Hiroshi Nishino, and Kazu Kurosawa, Heterocycl. Commun.,1999, 5,111-112.
• Simple Route to Azabicyclic Peroxides from Tetramic Acid Derivatives Using Manganese(III)-Based Molecular Oxygen Trapping Reaction, Firoz Alam Chowdhury, Hiroshi Nishino, and Kazu Kurosawa, Heterocycles1999, 51,575-591.
• A Novel Macrodiolide Synthesis Using the Mn(III)-Based Radical Cyclization of Terminal Alkadienes and Oligomethylene Di(3-oxobutanoate)s, Tomomi Yoshinaga, Hiroshi Nishino, and Kazu Kurosawa, Tetrahedron Lett.,1998, 39,9197-9200.
• One-Pot Synthesis of Azabicyclic Peroxides from Tetramic Acid Derivatives by Manganese(III)-Mediated Oxidative [2+2+2] Cycloaddition, Firoz Alam Chowdhury, Hiroshi Nishino, and Kazu Kurosawa, Tetrahedron Lett.,1998, 39,7931-7934.
• Mn(III)-Based Reactions of Alkenes and Alkynes with Thiols. An Approach toward Substituted 2,3-Dihydro-1,4-oxathiins and Simple Route to (E)-Vinyl Sulfides, Van-Ha Nguyen, Hiroshi Nishino, Shougo Kajikawa, and Kazu Kurosawa, Tetrahedron1998, 54,11445-11460.
• Syntheses of Ethyl 2,5-Diaryl-3-furancarboxylates and Methyl 5-Aryl-4-(w-hydroxyalkyl)-2-methyl-3-furancarboxylates, Shogo Kajikawa, Yoshikazu Noiri, Hidenari Shudo, Hiroshi Nishino, and Kazu Kurosawa, Synthesis,1998, 1457-1462.
• Mn(III)-Based Reaction of Alkenes with Pyrrolidinedione Derivatives. Formation of Bicyclic Peroxides and the Related Compounds, Van-Ha Nguyen, Hiroshi Nishino, and Kazu Kurosawa, Hetrecycles,1998,48,465-480.
• Manganese(III)-Based Facile Synthesis of 3-Cyano-4,5-dihydrofurans and 4-Cyano-1,2-dioxan-3-ols Using Alkenes and Acylacetonitrile Building Blocks, Van-Ha Nguyen, Hiroshi Nishino, and Kazu Kurosawa, Synthesis,1997,899-908.
• Mn(III)-Induced Molecular Oxygen Trapping Reaction of Alkenes with 2,3-Pyrrolidinedione Derivatives. A Novel Entry to 1-Hydroxy-8-aza-2,3-dioxabicyclo[4.3.0]nonan-9-ones, Van-Ha Nguyen, Hiroshi Nishino, and Kazu Kurosawa, Tetrahedron Lett.,1997,38,1773-1776.
• Reaction of Phenylethyne with 2,4-Pentanedione in the Presence of Manganese(III) Acetate and Oxygen, Chang-Yi Qian, Bo Han, Yu Fen Zhao, Yoshikazu Noiri, Hiroshi Nishino, and Kazu Kurosawa, Chainese Chem. Lett.,1997,8,189-190.
• Manganese(III)-Mediated Intermolecular Cyclization Reactions of Alkenes and Active Methylene Compounds, Jie Ouyang, Hiroshi Nishino, and Kazu Kurosawa, J. Heterocycl.Chem.,1997,34,81-86.
• Manganese(III)-Based Oxidative Free-Radical Cyclizations at High Temperature and Room Temperature, Hiroshi Nishino, 6th International Symposium on Fine Chemistry and Functional Polymers,1996,78-79.
• Formation of Tetrahydrofuran Derivatives and Acetonylation of Alkenes Using Carbon Radicals Derived from Manganese(III) Oxidation of Diketene, Hiroshi Nishino, Van-Ha Nguyen, Shinji Yoshinaga, and Kazu Kurosawa, J. Org. Chem.,1996,61,8264-8271.
• Syntheses of 4-(2-Hydroperoxy-2,2-diarylethyl)-3,5-dimethylpyrazoles, 4-(2-Hydroxy-2,2-diarylethyl)-3,5-dimethylpyrazoles and the Related Compounds, Jie Ouyang, Hiroshi Nishino, and Kazu Kurosawa, J. Heterocycl. Chem.,1996,33,1291-1302.
• Manganese(III)-Mediated Oxidative Radical Cyclization 3. Synthesis of 3- Azabicyclo[3.3.0]octan-2-ones and the Related Compounds in the Reaction of 1,1,6,6- Tetraaryl-1,5-hexadienes with N,N'-Disubstituted Malonamides, Hiroshi Nishino, Kiyotaka Ishida, Hideaki Hashimoto, and Kazu Kurosawa, Synthesis,1996,888-896.
• Convenient Synthesis of 3-Cyano-4,5-dihydrofurans and 4-Cyano-1,2-dioxan-3-ols Using Acylacetonitrile Building Block, Van-Ha Nguyen, Hiroshi Nishino, and Kazu Kurosawa, Tetrahedron Lett.,1996,37,4949-4952.
• 1995-1991
• 1990-1986
• 1985-1983

Membership

• The Chemical Society of Japan
• The Americal Chemical Society
• The Society of Synthetic Organic Chemistry, Japan
• The Malacological Society of Japan

Personal History

    Education:

1975-1979

Department of Chemistry, Faculty of Science, Kumamoto University
Awarded the degree of B.Sc. in chemistry

1979-1981

Department of Chemistry, Faculty of Science, Kumamoto University
Awarded the degree of M.Sc. in chemistry for a thesis entitled "Oxidation of 9-Xanthenones with Manganese(III) Acetate. Regioselective Carboxylation." Work supervised by Professor Kazu Kurosawa

1988

Awarded the degree of Ph.D. in chemistry by Department of Chemistry,
Faculty of Science, Tohoku University for a thesis entitled "Study of Organic Reactions Using Manganese(III) Complexes." Work supervised by Professor Kazu Kurosawa and Professor Sho Ito

    Research and Professional Experience:

1981-1995

Research Associate at the Department of Chemistry, Faculty of Science,
Kumamoto University, working with Professor Kazu Kurosawa on studying free-radical carbon-carbon bond formation of organic compounds using metal oxidants, catalytic oxidation of unsaturated hydrocarbons using manganese complexes, and photochemical reaction of organic compounds.

1996-1999/6

Associate Professor at the Department of Chemistry, Faculty of Science, Kumamoto University

1999/7-present

Professor at the Department of Chemistry, Faculty of Science, Kumamoto University

1988-1989

Overseas Research Personnel of the Ministry of Education, Science and Culture, Japan, at the Department of Chemistry, University of Houston, U.S.A., working with Professor Jay K. Kochi on studying charge-transfer complexes of dioxochromium(VI) salts with organic molecules

1989-1990

Postdoctoral Fellow of Rice University, U.S.A., working with Professor Tohru Fukuyama on studying total synthesis of Porothramycins

1996

Overseas Research Personnel of the Ministry of Education, Science, Sports and Culture, Japan,
at the Department of Chemistry, Texas A&M University, working with Professor Derek Harold R. Barton;
at the Department of Chemistry, Ohio State University, working with Professor Leo A. Paquette;
at the Department of Chemistry, Brandeis University, working with Professor Barry B. Snider.

    Awards:

1994

Award for Encouragement of Kyushu-Yamaguchi Branches of the Society of Synthetic Organic Chemistry, Japan, on Development of Free-Radical Reactions Using Manganese(III) Complexes

【Kurosawa/Nishino Research Group】

Hobby

• Study of the Land Mollusca (Land Snail)
• Ecological Photography of Living Things
• Play Tennis, Swimming, Softball, Skating, Football, Climbing, Caving, Jogging, etc
• Drive on Kawasaki Vulcan 400
• Listening Classic Rock & Roll (BT, RS, CCR, GFR, DP, VH, EP, CT, DL, SS, etc)

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